Compared to peripheral pain, trigeminal pain elicits higher levels of fear, which is assumed to enhance the interruptive effects of pain on concomitant cognitive processes. In this fMRI study we examined the behavioral and neural effects of trigeminal (forehead) and peripheral (hand) pain on visual processing and memory encoding.
A recent study, using laboratory mice, discovered a physical link within the brain that may explain why headaches are more severe than pain we experience in other parts of the body. Pain perception involves both the physical sensation of pain and the emotional response to that pain. There are physical structures within the brain that regulate both, but until now, a direct link between the two had only been hypothesized.
The burden of cluster headache is associated with significant co-morbidity, including substance use disorders and suicidal ideation, and treatment patterns indicating low use of recognized cluster headache treatments.