Peer-reviewed medical journal articles on cluster headache and related conditions.
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Article topics
- Sumatriptan Inhibits TRPV1 Channels in Trigeminal Neurons May 1, 2012To understand a possible role for transient potential receptor vanilloid 1 (TRPV1) ion channels in sumatriptan relief of pain mediated by trigeminal nociceptors.
- Intravenous Therapies in the Management of Neuropathic Pain March 28, 2012Neuropathic Pain is a term referred to “pain arising as a direct consequence of a lesion affecting the somatosensory system”. As a first line option, oral medications are mostly used, as they are easily available, relatively safe, and do not need much resources. They include antidepressants in the form of tricyclics, newer selective reuptake inhibitors ...
- Differences in Clinical Characteristics and Frequency of Accompanying Migraine Features in Episodic and Chronic Cluster Headache March 9, 2012Data on clinical differences between episodic (eCH) and chronic cluster headache (cCH) and accompanying migraine features are limited. History and clinical features of 209 consecutive cluster headache patients (144 eCH, 65 cCH; male:female ratio 3.4 : 1) were obtained in a tertiary headache centre by face-to-face interviews. Relationship between occurrence of accompanying symptoms, pain intensity, ...
- Cluster Headache in the United States of America: Demographics, Clinical Characteristics, Triggers, Suicidality, and Personal Burden* January 1, 2012A total of 1134 individuals completed the survey (816 male, 318 female). Some key highlights from the survey include the following: diagnostic delay, suicidality, eye color, laterality, attack profile, triggers, comorbidities, and personal burden.
- Tooth injury increases expression of the cold sensitive TRP channel TRPA1 in trigeminal neurons December 1, 2011Transient receptor potential (TRP) channels, a family of structurally related proteins have been implicated in the sensation of pain and hyperalgesia caused by exogenous and endogenous agonists, as well as touch, pH, and temperature. The objective of this study was to determine the effects of tooth injury on the expression of the cold sensitive channel ...
- The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system October 25, 2011The California bay laurel or Umbellularia californica (Hook. & Arn.) Nutt., is known as the ‘headache tree’ because the inhalation of its vapours can cause severe headache crises. However, the underlying mechanism of the headache precipitating properties of Umbellularia californica is unknown. The monoterpene ketone umbellulone, the major volatile constituent of the leaves of Umbellularia ...
- Analytic cognitive style in cluster headache August 18, 2011Previous reports on cluster headache have shown a hypothalamic dysfunction and a hitherto unrecognized defect in the information processing pathways measured by event-related potentials. As of today, the causes are still unknown; likewise, studies on the psychological factors involved in CH have not yielded relevant data.
- Stereotactic radiosurgery for intractable cluster headache: an initial report from the North American Gamma Knife Consortium June 1, 2011The aim of this study was to evaluate the outcomes of Gamma Knife surgery (GKS) when used for patients with intractable cluster headache (CH).
- Consequences of Hyperoxia and the Toxicity of Oxygen in the Lung April 30, 2011Oxygen (O2) is life essential but as a drug has a maximum positive biological benefit and accompanying toxicity effects. Oxygen is therapeutic for treatment of hypoxemia and hypoxia associated with many pathological processes. Pathophysiological processes are associated with increased levels of hyperoxia-induced reactive O2 species (ROS) which may readily react with surrounding biological tissues, damaging ...
- Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study February 24, 2011Occipital nerve stimulation (ONS) has raised new hope for drug-resistant chronic cluster headache (drCCH), a devastating condition. However its mode of action remains elusive. Since the long delay to meaningful effect suggests that ONS induces slow neuromodulation, we have searched for changes in central pain-control areas using metabolic neuroimaging.