Peer-reviewed medical journal articles on cluster headache and related conditions.
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Article topics
- CINTHA Trial. A randomised clinical study to investigate the effectiveness of sphenopalatine ganglion stimulation in cluster headache March 1, 2017Chronic cluster headache (CCH) is a debilitating disorder with a significant impairment for the patient leading to low quality of life. The sphenopalatine ganglion (SPG) proved to play an important role in CCH pathophysiology.
- Ipsilateral Alteration of Resting State Activity Suggests That Cortical Dysfunction Contributes to the Pathogenesis of Cluster Headache March 1, 2017The pathomechanism of cluster headache (CH) is not entirely understood, but central and peripheral components were suggested. A recent report showed that transcranial magnetic stimulation measured cortical excitability was increased in the hemisphere ipsilalteral to the pain. In the current study we set out to investigate the amplitude of resting brain fMRI activity to find ...
- Sphenopalatine ganglion stimulation for treatment of cluster headache, a postoperative observational study March 1, 2017Cluster headache is a rare form of primary headache characterised by intense unilateral pain and autonomous nerve symptoms. Pharmacological treatments are sometimes insufficient, which calls for surgical alternatives in treatment refractory cases. Stimulation of the sphenopalatine ganglion (SPG) is a new method shown to be effective for preventing and treating attacks.
- Effects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study February 14, 2017In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus standard of care (nVNS + SoC) than with SoC alone. Given the intensely painful and frequent nature of chronic cluster headache attacks, additional patient-centric outcomes, including the time to and ...
- Botulinum Toxin Type A Block of the Otic Ganglion in Chronic Cluster Headache: Safety Issues February 13, 2017Condition: Cluster HeadacheInterventions: Drug: Botulinum Toxin Type A 25 IU; Drug: Botulinum Toxin Type A 12.5 IUSponsors: Norwegian University of Science and Technology; St. Olavs HospitalRecruiting – verified April 2017 Source: Cluster Headache Clinical Trials
- Cluster headache and other TACs: Pathophysiology and neurostimulation options February 2, 2017The trigeminal autonomic cephalalgias (TACs) are highly disabling primary headache disorders. There are several issues that remain unresolved in the understanding of the pathophysiology of the TACs, although activation of the trigeminal–autonomic reflex and ipsilateral hypothalamic activation both play a central role. The discovery of the central role of the hypothalamus led to its use ...
- Treatment of intractable chronic cluster headache by occipital nerve stimulation: a cohort of 51 patients February 1, 2017Chronic cluster headache is a rare, highly disabling primary headache condition. When medically intractable, occipital nerve stimulation can offer effective treatment. Open-label series have provided data on small cohorts only.
- Cluster Headache and Other TACs: Pathophysiology and Neurostimulation Options February 1, 2017The trigeminal autonomic cephalalgias (TACs) are highly disabling primary headache disorders. There are several issues that remain unresolved in the understanding of the pathophysiology of the TACs, although activation of the trigeminal–autonomic reflex and ipsilateral hypothalamic activation both play a central role. The discovery of the central role of the hypothalamus led to its use ...
- Identifying a gene expression signature of cluster headache in blood January 11, 2017Cluster headache is a relatively rare headache disorder, typically characterized by multiple daily, short-lasting attacks of excruciating, unilateral (peri-)orbital or temporal pain associated with autonomic symptoms and restlessness. To better understand the pathophysiology of cluster headache, we used RNA sequencing to identify differentially expressed genes and pathways in whole blood of patients with episodic (n = 19) ...
- A genetic CLOCK variant associated with cluster headache causing increased mRNA levels January 1, 2017Cluster headache is characterized by recurrent unilateral headache attacks of severe intensity. One of the main features in a majority of patients is a striking rhythmicity of attacks. The CLOCK (Circadian Locomotor Output Cycles Kaput) gene encodes a transcription factor that serves as a basic driving force for circadian rhythm in humans and is therefore particularly interesting ...